Break out the Hateraid.
The myriad haters of all things Williams sisters are gleefully munching on Hater Tots after 2005 US Open champ Kim Clijsters of Belgium upset third seeded Big Sis 0-6,6-0, 4-6.
It ends Venus' run on the singles side of the 2009 US Open, but she and Little Sis are still alive in their quest to capture their first US Open women's doubles tournament title since 1999.
Meanwhile Williams family honor falls to Little Sis once again.
The defending US Open champ is in the quarterfinal round after beating down Daniela Hantuchova 6-2, 6-0. She took the last 10 games to close out the match.
With Dinara Safina getting beat (again) Serena is now the highest ranked player left on the women's side.
Little Sis is on a roll right now, but she still has some work to do before she can match Big Sis as a repeat US Open champion.